We have highlighted the MRI finding of typical punctate foci of bright signal in hippocampus seen on DWI in patients diagnosed with TGA. In 6 patients who had DWI MRI at both B values, scans at B value of 1000 s/mm 2 revealed abnormality in 4 patients, while higher B value imaging improved sensitivity in one patient and one patient had a negative scan at both B values. Nine patients showed a single focus, 1 patient showed three foci and 1 patient showed four foci. 10 patients showed foci in left hippocampus. If localizing symptoms, consider alternative diagnosis.
11 of the 12 patients showed punctate foci of restricted diffusion in hippocampus (mean size 3.7 mm (range 2-6.5 mm). Periods of time typically less than 24 hrs, but typically lasts 4-6 hrs. The median time interval between the onset of symptom and MRI scan was 47.5 hours, range 25-114 hours. The mean age was 65.67 years (range 61-74 years).
DWI were acquired at B value of 1000 s/mm 2 in 4 patients, 2000 s/mm 2 in 2 patients and both 10 s/mm 2 in 6 patients. MRI brain was performed with a 3T scanner on 11 patients and 1.5T scanner on 1 patient. MRI findings in 12 patients with clinical diagnosis of TGA were retrospectively analysed. Aim of this study is to identify and describe the MRI findings in patients with Transient Global Amnesia (TGA), specifically on Diffusion Weighted Imaging (DWI) sequence.
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